By Hans-Peter Lipp
Containing the newest findings at the toxicity of a variety of chemotherapeutic brokers, this up to the moment reference bargains professional analyses at the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds. Anticancer Drug Toxicity ·explores healing drug tracking (TDM) as a mode of maximizing the efficacy, and minimizing the risks, of chemotherapy ·presents an enormous volume of medical pharmacokinetic facts on cytostatic medications ·offers a entire category of toxicity styles linked to using cytotoxic medicines ·analyzes the pharmacokinetics of alkylating brokers, platinum compounds, anthracyclines, antimetabolites, semisynthetic podophyllotoxin- and camptothecin derivatives, mitotic inhibitors, and different cytotoxic brokers ·highlights the pharmacogenetics of 6-mercaptopurine and its medical value ·explicates toxicity when it comes to the lungs, kidneys, middle, and gonads ·examines issues because of asparaginase arrangements ·reviews varieties of secondary malignancy similar to leukemias, ovarian melanoma, testicular melanoma, breast melanoma, secondary strong neoplasias, and Hodgkin's sickness ·clarifies the knowledge of toxicity as a vital point in supportive administration of melanoma treatment ·and extra! An tremendously sensible advisor for daily scientific perform, in addition to a resource of concept for extra study within the box, Anticancer Drug Toxicity is a useful reference for medical and scientific oncologists; health facility, business, and scientific pharmacologists and pharmacists; toxicologists; pharmaceutical chemists; radiologists; and graduate and scientific college scholars in those disciplines.
Read or Download Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics PDF
Best toxicology books
New information always point out that antioxidants may possibly give a contribution to mark downs in melanoma hazards and that persistent intake of low degrees of chemical cancer causing agents in our vitamin could give a contribution to an elevated possibility of constructing particular kinds of cancers. examine additionally exhibits that during the USA at the present time, the prime factors of demise are melanoma and middle sickness.
There's a urgent desire between researchers interested by toxicologic research for a sequence of guides that organizes and provides info at the most recent experimental methodologies. to deal with the desires of researchers in toxicology, toxicologic pathology, pharmacology and scientific biochemistry, this new sequence ''Methods in Toxicology'' offers finished descriptions of cutting-edge tools for comparing drug and chemical toxicity.
Learn and laws in foodstuff microbiology proceed to adapt, and outbreaks of foodborne sickness position additional strain at the to supply microbiologically secure items. This moment quantity within the sequence Advances in Microbial nutrients security summarises significant fresh advances during this box, and enhances quantity 1 to supply a vital review of advancements in foodstuff microbiology.
- Drug Discovery and Evaluation: Pharmacological Assays
- The Laboratory Mouse (Handbook of Experimental Animals)
- Hair Analysis in Clinical and Forensic Toxicology
- Dreisbach's Handbook of Poisoning: Prevention, Diagnosis and Treatment
- Safety Evaluation in the Development of Medical Devices and Combination Products
Extra info for Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics
1956). Studies on the accumulation, metabolism and excretion of inorganic mer cury after prolonged subcutaneous administration to rats. Ada Pharmacol. ToxicoL 12, 411-427. Gerson, R. , and Shaikh, Z. A. (1982). Uptake and binding of cadmium and mercury to metallothionein in rat hepatocyte primary cultures. J. 208, 465-472. Goyer, R. , Leonard, D. , Moore, J. , and Krigman, M. R. (1970). Lead dosage and the role of the intranuclear inclusion body. Arch. Environ. Health. 20, 705-711. Goyer, R. , Haust, M.
Environ. Health Per spect. 78, 85-90. Chan, H. , Goyer, R. , and Cherian, M. G. (1993). Nephrotoxicity in rats following liver transplantation from cadmium-exposed rats. Toxicol. Appi Pharmacol. 123, 89-96. , Nartey, N. , and Cherian, M. G. (1986). Metallothionein levels in liver and kidney of Canadians: A potential indicator of environmental exposure to cadmium. Arch. Envi ron. Health 41,319-323. Cory-Slechta, D. A. (1990). Lead exposure during advanced age: Alterations in kinetics and biochemical effects.
1981). Cellular uptake of cadmium and zinc. Biol. Trace Elem. Res. 3,197-216. Cotzias, G. C , Borg, D. C , and Selleck, B. (1961). Virtual absence of turnover in cadmium metabolism. ]. Physiol. 201, 927-930. Deren, J. J. (1968). Development of intestinal structure and function. " Vol. 3, "Alimentary Canal" (C. ), pp. 1099-1123. Williams and Wilkins, Baltimore. Eidson, A. E, Griffith, W. , Hahn, F. , and Pickrell, J. A. (1989). A model for scaling the results of uranium excretion rate studies in beagle dogs to man.
Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics by Hans-Peter Lipp