By Icon Health Publications
This can be a 3-in-1 reference publication. It supplies a whole scientific dictionary protecting thousands of phrases and expressions in relation to arsenic. It additionally provides broad lists of bibliographic citations. ultimately, it presents details to clients on find out how to replace their wisdom utilizing a number of net assets. The ebook is designed for physicians, scientific scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to get to grips with learn devoted to arsenic. in case your time is effective, this booklet is for you. First, you won't waste time looking out the web whereas lacking loads of suitable info. moment, the e-book additionally saves you time indexing and defining entries. ultimately, you won't waste money and time printing 1000's of web content.
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Additional info for Arsenic - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
In addition to elucidating the basic regulatory logic underlying the mammalian response to oxidative stress, this project will have two practical outcomes relevant to the mission of the Superfund Research Program; it will create: 1) gene arrays, cell lines and transgenic mice that can be used as biosensors for monitoring exposure to toxicants that cause oxidative stress; 2) strains of mice that are deficient in activation of the protective response to oxidative 24 Arsenic stress. Such mice should be supersensitive to pro-oxidants and thus will facilitate the detection and evaluation of new suspected toxicants and mixtures of chemicals from Superfund Sites for their ability to cause oxidative stress mediated toxicity.
This study utilizes a unique panel of human B-lineage lymphocyte (BLL) cell lines that show large differences in their sensitivity to apoptosis induction by various chemicals to test the hypothesis that the differential activation of specific mitogen-activated protein (MAP) kinases is a critical factor in determining chemical sensitivity in BLLs. The activation of the three major MAP- kinase pathways, ERK1/2, JNK1/2, and -38 following exposure of the BLL-cell lines to the environmental pollutants arsenic and cadmium, and selected drugs that share with these metals the ability to perturb mitochondrial function will be examined.
Our specific aims in the next funding period are to increase accrual to ECOG therapeutic and other trials, and to serve as study chairs of several ECOG trials based entirely or in part on pilot data from this institution, including a study of thrombo-poietin in elderly adults with acute myeloid leukemia, a study of theophylline in chronic lymphocytic leukemia, and a study of arsenic trioxide in relapsed acute pro-myelocytic leukemia. In addition, laboratory investigations in colon cancer, cervical cancer and leukemia utilizing fresh and banked samples from patients enrolled on ECOG studies group wide are proposed.
Arsenic - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications