By C. Gopinath, D. Prentice, D.J. Lewis
Our target in generating a color atlas of toxicological guidance itemize the investigations to be conducted pathology used to be to provide a listing of histopathologi in the course of the process the examine they usually mostly comprise: cal lesions which we had encountered through the years in scientific observations and behavior; nutrition consumption and physique quite a few laboratory animal species uncovered to an unlimited weight measurements; serum biochemistry; haema variety of prescribed drugs, agrochemicals and commercial tology; ECG and ophthalmology. on the finish of a examine, chemical compounds. whereas we think a color atlas is the correct complete macroscopic and microscopic examinations of ways to proportion our stories with others, it speedy organ weight analyses including tissues are essen grew to become transparent to us that for the atlas to be significant tial. via a long way the larger a part of the cloth utilized in this the linked textual content needs to be entire and comprise booklet is from toxicity experiences performed in recent times considerable literature references. and played in compliance with the nice Laboratory The atlas is meant for either the trainee and the perform criteria of governmental regulatory our bodies in skilled toxicological pathologist operating with lab Europe, Japan and North the United States. oratory animals within the pharmaceutical, agrochemical or Toxicity experiences are in general conducted in rats, chemical environment.
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Extra info for Atlas of Experimental Toxicological Pathology
Note the intracytoplasmic eosinophilic, spherical bodies with pyknotic nuclear remnants and the absence of any inflammatory response. 19 Apoptotic body in the liver of a rat treated with xylidine. Membrane-bound cell fragments with organelles and nuclear chromatin within the cytoplasm of a hepatocyte. 20 Cholestasis in the liver of a dog treated with a novel antidepressive pharmaceutical compound. Intracanalicular bile pigment appearing as olive green plugs. 21 Dilation of bile canaliculus with blunting and loss of microvilli in the liver of a rat with manganese chloride-induced cholestasis.
Respir. 488-505 7. Young, J. 1. (1981). Histopathologic examination of the rat nasal cavity. Fundam. Appl. Toxicol .. 1. 309-312 8. Buckley, L. A. Morgan, K. , Swenberg, J. A, James, R. A, Hamm, T. E. and Barrow, C. S. (1985). The toxicity of dimethylamine in F--344 rats and BsC3F, mice following a 1year inhalation exposure. Fundam. Appl. , 5, 341--352 9. Giddens, W. E. and Fairchild, G. A (1972). Effects of sulfur dioxide on the nasal mucosa of mice. Arch. Environ. , 25, 166-173 10. Morse, C. Boyd, M.
And Pappritz, G. (1976). Hairs causing pulmonary emboli. Vet. , 13, 394-400 55. Bernick, S. and Patek, P. R. (1961). Effect of cholesterol feeding in rat reticuloendothelial system. Arch. , 72, 78-88 56. , Fink, L. M. and Virmani. R. (1984). Perfluorochemicals. Arch. Pathol. Lab. , 108, 631-637 57. Leslie, G. , Noakes, D. , Pollitt, F. , Roe, F. J. C. and Walker, T. F. (1981). A two-year study with cimetidine in the rat: assessment for chronic toxicity and carcinogenicity. Toxicol. Appl. , 61, 119-137 58.
Atlas of Experimental Toxicological Pathology by C. Gopinath, D. Prentice, D.J. Lewis