By Bertram G. Katzung
The most present, authoritative, and finished pharmacology booklet for scientific, pharmacy, and different overall healthiness technology scholars. extensively revered for its readability, comprehensiveness, and association, this pharmacology path ebook offers the fundamental options that scholars want to know concerning the technology of pharmacology and their program. specializes in the elemental rules of every drug team in addition to the medical selection and use of substances in sufferers and the tracking in their results.
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Extra info for Basic & Clinical Pharmacology, Ninth Edition
Open arrows denote regulatory effects. ) The family of G proteins contains several functionally diverse subfamilies (Table 2–2), each of which mediates effects of a particular set of receptors to a distinctive group of effectors. Receptors coupled to G proteins comprise a family of "seven-transmembrane" or "serpentine" receptors, so called because the receptor polypeptide chain "snakes" across the plasma membrane seven times (Figure 2–11). Receptors for adrenergic amines, serotonin, acetylcholine (muscarinic but not nicotinic), many peptide hormones, odorants, and even visual receptors (in retinal rod and cone cells) all belong to the serpentine family.
The most important potential cause of failure to achieve a satisfactory response is that the diagnosis is wrong or physiologically incomplete. Drug therapy will always be most successful when it is accurately directed at the pathophysiologic mechanism responsible for the disease. When the diagnosis is correct and the drug is appropriate, an unsatisfactory therapeutic response can often be traced to compensatory mechanisms in the patient that respond to and oppose the beneficial effects of the drug.
5 ... >25 mg/L Gentamicin ... 5 ... Hydralazine 40 10 87 234 105 1 100 ng/mL ... 1 mg/L ... 5 mg/L ... 2 25 ng/mL ... 5 4 mg/L ... 9 ... 9 60 ng/mL ... 8 50 ng/mL ... 9 ... 9 20 ng/mL ... Pyridostigmi 14 ne 85 ... 9 75 ng/mL ... 1 100 ng/mL ... Rifampin ? 5 ... 32 15 10 ... 4 125 14 2 ng/mL ... 2 105 11 ... 1 10 mg/L >20 mg/L Tobramycin ... 2 ... 8 210 14 10 mg/L ... 9 100 mg/L ... Trimethopri m 100 69 44 9 130 11 ... Tubocurarine . . 6 mg/L ... 1 14 75 mg/L >150 mg/L Vancomycin . . 6 ... Verapamil 3 90 63 350 4 ...
Basic & Clinical Pharmacology, Ninth Edition by Bertram G. Katzung