Read e-book online Biochemistry and Molecular Biology of Antimicrobial Drug PDF

By Trevor J. Franklin, George Alan Snow

ISBN-10: 0387225544

ISBN-13: 9780387225548

The topic is one in all significant curiosity in uncomplicated microbiology and infectious illnesses and the e-book is a recognized vintage.

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Extra resources for Biochemistry and Molecular Biology of Antimicrobial Drug Action

Sample text

In a parallel experiment, penicillin was added at a concentration that would inhibit growth of Escherkiiia coli. 6), which was isolated as a water-soluble product of high molecular weight labelled with [^'''C]. No D-[''''C]alanine was liberated because the penicillin suppressed both the cross-linking transpeptidase reaction and the action of DD-carboxypeptidase. 5. Of the PBPs in Escherichia coli and many other bacteria, PBPla and FBPlb are the key enzymes involved in peptidoglycan biosynthesis.

Sulfazecin. 14); the name comes from monocyclic bacterial P-lactams) which are derived from bacteria and represent the simplest Plactam structures with antibacterial activity so far discovered. Many semisynthetic derivatives have been made and exhibit excellent anti-Gram-negative activity, with much weaker activity against Gram-positive bacteria. 14) appear to offer less activity and are of more historic than clinical interest. Interest in the p-lactam family remains intense and novel drugs with improved properties continue to be developed.

The mechanism of inhibition of the arabinosyl transferases by ethambutol remains to be established and will probably await the purification of the enzymes, which are predicted to be integral membrane proteins with multiple anchoring, transmembrane domains and an external domain. 6 The fungal cell wall as a target for antifungal drugs lope may increase cellular permeability to other drugs. This could account for the valuable clinical synergism that is achieved when ethambutol is combined with a drug of large molecular size such as rifampicin.

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Biochemistry and Molecular Biology of Antimicrobial Drug Action by Trevor J. Franklin, George Alan Snow


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