By William Dowhan (auth.), Jos A. F. Op den Kamp (eds.)
The complex examine Institute on "Structure, Biogenesis and Dynamics of organic Membranes, held in Cargese from June 14-26, 1993, has been facing 4 significant subject matters in membrane biochemistry at the present time: lipid dynamics and lipid-protein interactions, protein translocation and insertion, intracellular site visitors aud protein constitution and folding. the teachers mentioned those subject matters ranging from numerous disciplines, together with biochemistry, mobilephone biology, genetics, and biophysics. This wayan interdisciplinary and extremely inte~sting view on organic membrane platforms was once received. firstly an intensive evaluate of -mainly biophysical -techniques which are used to check dynamic strategies in membranes was once offered. subtle methods similar to ESR and NMR were utilized succesfully to solve info of particular lipid-protein interactions. x ray research presents specific structural details of numerous proteins and the potential implications for protein features. details acquired this manner is complemented by means of stories on mechanisms and kinetics of protein folding. The latter details is essential while discussing protein translocation and insertion: proces:;es during which folding and unfolding play crucial roles. broad perception was once provided within the advanced equipment of phospholipid biosynthesis. specifically, the appliance of refined genetic options has allowed a greater figuring out of the mechanisms regulating the unreal equipment and precise reports on various mutants, missing a number of of the basic enzymes, have ended in the start of a bL!:
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The complicated research Institute on "Structure, Biogenesis and Dynamics of organic Membranes, held in Cargese from June 14-26, 1993, has been facing 4 significant themes in membrane biochemistry at the present time: lipid dynamics and lipid-protein interactions, protein translocation and insertion, intracellular site visitors aud protein constitution and folding.
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Additional resources for Biological Membranes: Structure, Biogenesis and Dynamics
This way, trace amounts of radioactive Pc. PE, PS and SM, when present in donor vesicles. are transferred in one single incubation into the outer layer of the erythrocyte membrane. Following subsequent incubation, washing of the erythrocytes and phospholipase 36 treatment, the quantitation of residual radioactivity of each phospholipid class is carried out in order to determine the relative amount that had been migrated towards the inner membrane leaflet [Tilley et al 1986]. The procedure is outlined schematically in Fig.
W' I • : Fig. 5. Labelling pattern of inositol-containing sphingolipids in subcellular fractions of Saccharomyces cerevisiae sec 14. Lipids of the plasma membrane and of microsomes were saponified prior to thin-layer chromatographic separation. In the plasma membrane of secJ4 cells labeled sphingolipids are detected when cells are grown at 24°C, but not when they are grown at the non-permissive temperature. This result indicates, that also late steps of sphingolipid transport to the plasma membrane are governed by the protein secretory machinery.
The position of the linkage between mannose and the second inosito)phosphate group in M(IP)2C is hypothetical. Becker and Lester (1980) presented evidence that a yeast microsomal fraction contains an activity to introduce inositolphosphate from phosphatidylinositol into sphingolipids. Recently Puoti et al. (1991) reported that temperature-sensitive yeast secretory mutants (Schekman, 1985) blocked in early steps of the secretory pathway of proteins are unable to NATO AS! Series, Vol. H 82 Biological Membranes: Structure.
Biological Membranes: Structure, Biogenesis and Dynamics by William Dowhan (auth.), Jos A. F. Op den Kamp (eds.)