Read e-book online Cardiovascular toxicology PDF

By Daniel Acosta

ISBN-10: 0203361458

ISBN-13: 9780203361450

ISBN-10: 0415248698

ISBN-13: 9780415248693

ISBN-10: 1560328053

ISBN-13: 9781560328056

Acosta's renowned quantity presents details on cardiovascular toxicology for clinicians, public well-being officers, commercial and experimental toxicologists, in addition different pros. This re-creation highlights significant developments at the molecular points of toxicity to the cardiovascular procedure, together with genomics info the place applicable. The publication is split into 5 sections: an creation that emphasizes the necessity to discover organic mechanisms as components within the toxicity of chemical compounds and medication to the cardiovascular method, via sections addressing equipment, rules of phone damage, cardiotoxicity of chemical brokers, and vascular toxicity.
The editor and all contributing authors are good proven specialists of their respective fields therefore making sure Cardiovascular Toxicology because the such a lot authoritative and updated evaluation of this quarter of systematic toxicology.

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1997). Overall, these studies demonstrate that measuring hypertrophic growth in vitro must include multiple end-points rather than just one particular marker. MELCHERT, CAI YUAN, AND DANIEL ACOSTA, JR. “functional” end-point, such as total protein content or rates of protein synthesis, and at least one marker of expression of fetal program genes, such as atrial natriuretic factor. Possibilities for cardiac myocyte growth in response to toxicants or toxicant-induced injury Little is known regarding cardiac myocyte hypertrophic growth following exposure of the heart to exogenous substances, including xenobiotics.

Death by design. Programmed cell death in cardiovascular biology and disease. Circulation Research 81:137–144. D. 1993. Transforming growth factor- in cardiac ontogeny and adaptation. Circulation Research 73:783–791. D. 1994. Transforming growth factor- response elements of the skeletal -actin gene. The Journal of Biological Chemistry 269:16754–16760. J. 1998. Androgen receptors mediate hypertrophy in cardiac myocytes. Circulation 98:256–261. MELCHERT, CAI YUAN, AND DANIEL ACOSTA, JR. R. 1986. 1-Adrenergic stimulation of rat myocardial cells increases protein synthesis.

Transcriptional regulation during cardiac growth and development. Annual Review of Physiology 55:77–95. , and Anversa, P. 1997. Angiotensin II activates programmed myocyte cell death in vitro. Experimental Cell Research 231:363–371. H. 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362:849–852. , and Kester, M. 1996. Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades. Biochemical Journal 316:13–17.

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Cardiovascular toxicology by Daniel Acosta

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