Download e-book for iPad: Casarett & Doull's Toxicology: The Basic Science of Poisons by Curtis D. Klaassen

By Curtis D. Klaassen

ISBN-10: 0071470514

ISBN-13: 9780071470513

The such a lot entire, relied on reference textual content overlaying the total span of clinical toxicology

A Doody's center identify crucial buy for 2011!

"This reference stands by myself because the easy textual content within the box of toxicology. This authoritative reference is written by way of many uncommon pros within the box, and provides transparent, concise descriptions of the main options in toxicology. it truly is large and entire, overlaying a huge diversity of issues in adequate element. either as a reference and as an academic instrument, this e-book exceeds its target of serving as a reference for toxicologists, different scientists, and scholars of the self-discipline. three Stars."--Doody's evaluate Service

Long verified because the most desirable within the box, Casarett & Doull's Toxicology equips you with an unsurpassed figuring out of contemporary toxicology, together with the rules, techniques, mechanisms, and modes of inspiration which are the basis of the self-discipline. the recent 7th version gains is up-to-date all through and comprises many new participants and new content material on chemical terrorism.

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Additional resources for Casarett & Doull's Toxicology: The Basic Science of Poisons (7th Edition)

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Gunther RT: The Greek Herbal of Dioscorides. New York: Oxford University Press, 1934. Guthrie DA: A History of Medicine. Philadelphia: Lippincott, 1946. Handler P: Some comments on risk assessment, in The National Research Council in 1979: Current Issues and Studies. Washington, DC: NAS, 1979. Hutt PB, Hutt PB II: A history of government regulation of adulteration and misbranding of food. Food Drug Cosmet J 39:2–73, 1984. Kallet A, Schlink FJ: 100,000,000 Guinea Pigs: Dangers in Everyday Foods, Drugs and Cosmetics.

Blue-shaded area is representative of the concentration of chemical at the target site necessary to elicit a toxic response. exposures is the frequency of exposure. The relationship between elimination rate and frequency of exposure is shown in Fig. 2-2. A chemical that produces severe effects with a single dose may have no effect if the same total dose is given in several intervals. For the chemical depicted by line B in Fig. 2-2, in which the half-life for elimination (time necessary for 50% of the chemical to be removed from the bloodstream) is approximately equal to the dosing frequency, a theoretical toxic concentration (shown conceptually as two Concentration Units in Fig.

A mechanistic toxicologist is concerned with identifying and understanding the cellular, biochemical, and molecular mechanisms by which chemicals exert toxic effects on living organisms (see Chap. 3 for a detailed discussion of mechanisms of toxicity). The results of mechanistic studies are very important in many areas of applied toxicology. , cancer, birth defects) observed in laboratory animals is directly relevant to humans. For example, the relative toxic potential of organophosphate insecticides in humans, rodents, and insects can be accurately predicted on the basis of an understanding of common mechanisms (inhibition of acetylcholinesterase) and differences in biotransformation for these insecticides among the different species.

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Casarett & Doull's Toxicology: The Basic Science of Poisons (7th Edition) by Curtis D. Klaassen


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