New PDF release: Clinical Pharmacology During Pregnancy

By Donald Mattison

ISBN-10: 0123860075

ISBN-13: 9780123860071

Clinical Pharmacology in the course of Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and different doctors without delay occupied with the care of ladies while pregnant. This booklet specializes in the influence of being pregnant on drug disposition and likewise contains assurance of remedies for illnesses of particular physique platforms in addition to crucial content material on dosing and efficacy.

The huge variety of this publication encompasses analgesics, antiasthmatics, antidepressants, middle and circulatory medicinal drugs, supplementations and natural vitamins, and extra. themes in chemotherapy and substance abuse are coated, as are study matters, together with medical trial layout and moral considerations.

  • Uses an evidence-based technique for therapeutics in the course of pregnancy
  • Includes a precis of particular medicinal drugs by way of indication with up to date details on dosing and efficacy in being pregnant for the given indication

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2 Codeine The active metabolites of codeine are morphine and the morphine metabolite morphine-6-glucuronide. The enzyme systems responsible for this metabolism are: CYP2D for codeine and UGT2B7 for morphine, codeine-6-gluronide, and ­morphine-6-glucuronide. Both of these systems are subject to genetic variation. Some patients are ultrarapid metabolizers of codeine and produce higher levels of morphine and active metabolites in a very short period of time after administration. These increased levels will produce increased side effects, especially drowsiness and central nervous system depression in both the mother and nursing child [18, 19].

27] Tracy TS, Venkataramanan R, Glover DD, Caritis SN for the National Institute for Child Health and Human Development Network of Maternal-FetalMedicine Units. Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A activity) during pregnancy. Am J Obstet Gynecol 2005;192: 633–9. [28] Villani P, Floridia M, Pirillo MF, Cusato M, Tamburrini E, Cavaliere AF, et al. Pharmacokinetics of nelfinavir in HIV-1 infected pregnant and nonpregnant women. Br J Clin Pharmacol 2006;62:309–15. , et al.

Effect of labor epidural analgesia with and without fentanyl on infant breastfeeding: a prospective, randomized, double-blind study. Anesthesiology 2005;103:1211–7. [12] Wilson MJ, MacArthur C, Cooper GM, Bick D, Moore PA, Shennan A, et al. Epidural analgesia and breastfeeding: a randomised controlled trial of epidural techniques with and without fentanyl and a non-epidural comparison group. Anaesthesia 2010;65:145–53. [13] Chang ZM, Heaman MI. Epidural analgesia during labor and delivery: effects on the initiation and continuation of effective breastfeeding.

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Clinical Pharmacology During Pregnancy by Donald Mattison

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