By Eric F. Johnson, Michael R. Waterman
The seriously acclaimed laboratory regular for greater than 40 years, equipment in Enzymology is among the so much hugely revered guides within the box of biochemistry. on the grounds that 1955, each one quantity has been eagerly awaited, often consulted, and praised through researchers and reviewers alike. Now with greater than three hundred volumes (all of them nonetheless in print), the sequence includes a lot fabric nonetheless suitable today—truly an important booklet for researchers in all fields of existence sciences. Key gains* Human Genomics and Genetics* constitution and Mechanism* legislation of Expression* Metabolism* Invertibrate P450s
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Dispos. 28, 1493 (2000). Lang, K. Klein, J. Fischer, A. K. Niissler, P. Neuhaus, U. Hofmann, M. Eichelbaum, M. Schwab, and U. M. Zanger, Pharmacogenetics 11, 399 (2001). 10T. Aoyama, S. Yamano, P. S. Guzelian, H. V. Gelboin, and E J. Gonzalez, Proc. Natl. Acad. A. 87, 4790 (1990). 11 M. Shou, K. R. Korzekwa, K. W. Krausz, J. T. Buters, J. Grogan, I. Goldfarb, J. Hardwick, E J. Gonzalez, and H. V. Gelboin, Mol. Carcinog. 4, 241 (1996). 12 H. Yamazaki, K. Inoue, M. Hashimoto, and T. Shimada, Arch.
HOFFMAN and DIANE S. KEENEY Introduction Now that various genome projects have produced immense quantities of sequence from both the mouse and the human, with other species in progress, we have an unprecedented opportunity to analyze cytochrome P450 gene families. The available sequences, however, are neither complete nor perfectly assembled at this time, nor are they likely to be so in the immediate future. Because P450 genes in vertebrates frequently occur in tandem arrays that can include many pseudogenes, 1 they are particularly likely to be misassembled.
In the past decade, genetic factors for this variability have received much emphasis. One could envision that these would account for about 20-40% of the interindividual differences in drug metabolism and response, 1 but for certain drugs or classes of drugs, genetic factors will be of utmost importance for the outcome of the drug therapy. Cytochromes P450, responsible for 70-80% of all phase Idependent metabolism of clinically used drugs, play a central role. 2 Furthermore, the interindividual differences in susceptibility for carcinogens and environmental toxins are extensive, and cytochrome P450s play a key role in their bioactivation.
Cytochrome P450, Part C by Eric F. Johnson, Michael R. Waterman