Download e-book for iPad: Dermal Absorption (Environmental Health Criteria Series) by World Health Organization

By World Health Organization

ISBN-10: 9240682309

ISBN-13: 9789240682306

ISBN-10: 9241572353

ISBN-13: 9789241572354

This new quantity within the Environmental overall healthiness standards sequence provides an outline of dermal absorption and its attention within the hazard evaluation of chemical substances. It describes the equipment on hand to evaluate dermal absorption, the importance of pores and skin as a path of publicity and the translation of result of dermal absorption stories for possibility review. moreover, it provides and discusses present subject matters of curiosity within the box of dermal absorption.

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Extra info for Dermal Absorption (Environmental Health Criteria Series)

Example text

2002). At equilibrium, a saturated solution of chemical in a vehicle will be in equilibrium with the saturated concentration of solute in the stratum corneum (S,"). The maximum flux J*,,, is therefore given by Equation 5, which is derived from Equation 1. S* J*,* . Sn : ^Sr" [Equation 5] In principle, higher than maximum fluxes can be observedin intrinsically unstablesystems,suchas supersaturated solutions. 3 Physicochemical factors affecting skin permeation The physical and chemical properties of a compound and its vehicle have a decisive influence on its permeation tlrough the skin.

Permeationof a chemical through the stratum corneum is believed to depend upon permeant-specific factors, such as molecular weight, water and lipid solubility, polarity, and state of ionization (see chapter 4). The permeability properties of the stratum comeum are unchanged after excision from the body, and a good agreement between in vivo and in vitro experiments with the same chemicals has been observed (see chapter 8). Thus, in vitro experiments are appropriate to predict human dermal penetration.

Using this regimen, dose depletion is likely to occur. Finite dose experimentsmay be performed with all types of vertical/upright cells. , 2000; OECD, 2004c). Dose depletion is unlikely to occur. The dosing regimen and test substancepreparation are dictated by the type of experiment being performed. For example, in the assessmentof the absorption of a cosmetic ingredient for the purposes of risk assessment,a finite dose with an in-use application protocol and with the test compound in the formulation of interest would be preferred.

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Dermal Absorption (Environmental Health Criteria Series) by World Health Organization


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