By Melanie Johns Cupp (auth.), Melanie Johns Cupp PharmD, BCPS, Timothy S. Tracy PhD (eds.)
While revenues of supplements have skyrocketed lately, information regarding their defense and efficacy in people is mostly sparse compared to what's on hand for pharmaceuticals. supplements: Toxicology and scientific Pharmacology offers, in either finished and precis codecs, a wealth of aim info for a variety of important nonherbal supplements. The supplementations targeted have been selected for his or her recognition, toxicity, and the amount and caliber of data to be had, and contain such recognized brokers as DHEA,
androstenedione and different over the counter steroids, coenzyme Q10, fish oil, glucosamine and chondroitin, chitosan, chromium picolinate, creatine, vanadyl sulfate, similar, and melatonin. extra insurance is given to colloidal silver, shark cartilage, germanium, purple yeast rice extract, l-tryptophan, N,N-dimethylglycine, GHB and GBL, huperzine, hydrazine, methylsulfonylmethane, and pyruvate. each one monograph discusses the background of the compound; its chemical constitution; its present and promoted makes use of, assets, and chemical composition; and its toxicity, pharmacokinetics, and physiological position. additionally provided are case reviews in their adversarial results and interactions, in addition to info on their reproductive results, chemical and biofluid research, and regulatory prestige. each one bankruptcy relies on unique reports released in respected peer-reviewed journals, in addition to on meta-analyses, systematic reports, or different top of the range checks through well-known experts.
Authoritative and aim, supplements: Toxicology and scientific Pharmacology bargains physicians, pharmacologists, pharmacists, toxicologists, and health workers a treasure trove of uncommon-but reliable-scientific and medical details at the toxicity and value of ultra-modern major nonherbal nutritional supplements.
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Additional info for Dietary Supplements: Toxicology and Clinical Pharmacology
Liver transaminases (y-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase ) were unaffected. Effects of androstenedione and placebo on resistance training, muscle strength, muscle histochemistry, and body composition were similar. Ten additional subjects (mean age 23 yrs) were randomized to receive either a single dose of androstenedione 100 mg or placebo in a double-blind fashion. The additional study was conducted to measure the effect of androstenedione on hormone levels.
Andro-6 was discontinued by the manufacturer, but was still available through some Internet sites as of fall 2002. Other examples of androstendione products advertised on the Internet inc1ude Andro 250 (androstenedione 250 mg per capsule), GEN ANDRO*GEN (androstenedione 50 mg and 100 mg capsules), and Androplex 700 (androstenedione 50 mg, Tribulus terrestris 250 mg, and DHEA 50 mg per capsule). The potency and purity of androstenedione products vary among brands. Beginning in 1997, the UCLA Olympic Analytical Laboratory noted an increase in athletes testing positive for 19-norandrosterone, the major metabolite of the anabolic steroid nandrolone.
This was a surprising finding: nandrolone fell out of favor with athletes in the 1980s because its metabolite is detectable in the urine for weeks. Although 19norandrosterone of endogenous origin may be detectable in the urine, International Olympic Committee cutoffs were changed to reflect this in 1998. Because of reports that use of androstenedione could cause positive urine drug screens for 19norandrosterone, the Olympic Analytical Laboratory tested the potency and purity of androstenedione 100 mg capsules (six brands), 50 mg capsules (two brands), and 250 mg capsules (one brand) purchased from stores.
Dietary Supplements: Toxicology and Clinical Pharmacology by Melanie Johns Cupp (auth.), Melanie Johns Cupp PharmD, BCPS, Timothy S. Tracy PhD (eds.)