Download PDF by Wolfram Siede, Paul W. Doetsch: DNA Damage Recognition

By Wolfram Siede, Paul W. Doetsch

Stands because the so much entire advisor to the subject—covering each crucial subject with regards to DNA harm identity and repair.Covering a big selection of issues from micro organism to human cells, this ebook summarizes fresh advancements in DNA harm fix and popularity whereas supplying well timed stories at the molecular mechanisms hired through cells to differentiate among broken and undamaged websites and stimulate definitely the right fix pathways.

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Extra resources for DNA Damage Recognition

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An eloquent articulation of mechanisms that could promote the apparent rate acceleration by proteins in target site location came from the laboratories of Peter von Hippel and Otto Berg (4), who described several possible scenarios including sliding, hopping (or jumping), and looping (including intersegment transfer). Sliding is a term that denotes the following: after an initial random encounter with DNA, a protein remains closely associated with that DNA molecule, such that following the initial release of cations from the DNA, the protein is energetically free to slide on DNA, displacing and replacing an equal number of counterions as the protein translocates in one dimension along the DNA by Brownian motion.

31. Srivastava DK, Berg BJ, Prasad R, Molina JT, Beard WA, Tomkinson AE, Wilson SH. Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps. J Biol Chem 1998; 273(33):21203–21209. 32. Krokan H, Wittwer CU. Uracil DNA–glycosylase from HeLa cells: general properties, substrate specificity and effect of uracil analogs. Nucleic Acids Res 1981; 9(11): 2599–2613. 33. Delort AM, Duplaa AM, Molko D, Teoule R, Leblanc JP, Laval J. Excision of uracil residues in DNA: mechanism of action of Escherichia coli and Micrococcus luteus uracil–DNA glycosylases.

J Mol Biol 1998; 284(2):269–285. Parikh SS, Putnam CD, Tainer JA. Lessons learned from structural results on uracil– DNA glycosylase. Mutat Res 2000; 460(3–4):183–199. Drohat AC, Xiao G, Tordova M, Jagadeesh J, Pankiewicz KW, Watanabe KA, Gilliland GL, Stivers JT. Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187. Biochemistry 1999; 38(37):11876–11886. Dynamics of DNA Damage Recognition 17 25.

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DNA Damage Recognition by Wolfram Siede, Paul W. Doetsch


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